Hypophosphatasia (hypo-fahs-fuh-tay-shuh) or HPP is a metabolic bone condition that most often affects the development of bones and teeth. The signs and symptoms vary widely, with mild cases causing only dental abnormalities while the more severe types have life-threatening consequences. The hallmark of the disorder is bones that become soft or weakened, causing skeletal deformities, fractures, premature tooth loss and pain.
Typically, the earlier HPP symptoms become apparent, the more severe the condition. It is estimated that severe forms of HPP occur in approximately one of every 100,000 live births. While exact numbers are unknown, the more mild childhood and adult forms are probably more common and one out of every 200 Americans may be a carrier for HPP. Diagnosis is made through x-rays and blood testing and the disease is classified based on the age at which symptoms first appear.
For even more info, please check out the documents below.
A Genetic Overview of HPP
General HPP Brochure
Intro to HPP: A Clinical Overview
A Physician Guide to HPP
For Children: Talking About HPP
What is ALP – Trifold Brochure